MINNEAPOLIS -- Quarterback Kirk Cousins' U.S. Bank Stadium debut will come without three starters on the offensive line and the Minnesota Vikings' top running back.
Defensive end Everson Griffen, who hasn't practiced this week, is also being held out.
Prior to Saturday's afternoon game against the Jacksonville Jaguars, Minnesota declared running back Dalvin Cook wasn't expected to play along with center Pat Elflein (on the physically unable to perform list), right guard Mike Remmers and right tackle Rashod Hill.
Remmers returned to practice late in the week but wasn't participating in full-team drills. Hill has been out after rolling his ankle in practice earlier this week. The Vikings are being precautious with Cook, who has looked good in practice but is returning from knee surgery.
Other Vikings not expected to play: Stacy Coley, Brandon Zylstra, Mack Brown, Kentrell Brothers, Curtis Cothran, Blake Bell, Josiah Price and Tashawn Bower.
Griffen hasn't been seen during training camp in recent days and the Star Tribune reported that Griffen suffered a cut on his leg that got infected.
Price left practice clutching his knee as he was carted off and reports say he's lost for the season with a knee injury.
Without Cook and Brown, Roc Thomas and Mike Boone will get another prime opportunity as they compete for the third running back spot.