The 41-year-old Helton will replace Mike Sanford, who was fired on Sunday after going 9-15 in two years at Western Kentucky.
“When determining our next head football coach, there were many qualities we felt this person must have. Certainly they needed to have an excellent football mind, but also be a tremendous person who was respected inside and outside of the locker room. We found that person in Tyson Helton,” Western Kentucky athletic director Todd Stewart said in a statement. “His background as an innovative offensive mind and a great motivator of his players fit our mission to find the next great leader for our football program. We are thrilled to bring Tyson and his wonderful family back to WKU.”
Helton, who is the younger brother of USC head coach Clay Helton, spent the 2018 season as the offensive coordinator at Tennessee.
Before that he was the quarterbacks coach and passing-game coordinator at USC under his brother.
Tyson Helton was the offensive coordinator at Western Kentucky in 2014 and 2015 before taking the USC job.
He also spent time on coaching staffs at Cincinnati, UAB and Memphis.