Fulton, who missed the 2017 season because of the suspension for allegedly tampering with a drug-test sample early last year, hoped to have the second year waived.
The NCAA denied a request by Fulton's legal team to reconsider the original penalty so he could play this season.
According to the NCAA, a testing administrator witnessed Fulton pouring an unknown substance into his urine sample during a drug test in January of 2017.
Fulton's lawyers did not challenge that allegation, but questioned the rule -- 3.4 of NCAA's Drug-Testing protocol -- that was applied. The lawyers argued that Fulton was instead in violation of rule 3.3, which would have allowed for, at most, a one-year suspension.
In wake of the NCAA ruling, Fulton's lawyers "will attempt to file a waiver with the NCAA to still get Fulton on the field this year," according to the Times-Picayune.
Fulton, who was a five-star recruit in 2016, will have only one year of eligibility remaining if the waiver is denied. He played in five games for the Tigers as a freshman, making one tackle and one assist.